The Quantitative Pathology (QPATH) laboratory is currently working on several projects aiming to characterize the human medial temporal lobe and its associated pathology relating to Alzheimer’s disease. Our work uses magnetic resonance imaging, histology, and immunochemistry to validate biomarkers in preclinical disease stages. We are focused on characterizing early-stage Alzheimer’s disease before pathologies have caused cognitive impairment. Our studies have focused on selective vulnerability of neuronal populations within the entorhinal cortex, hippocampus, and locus coeruleus to p-tau, pTDP-43, and cerebrovasculature. Specifically, we have mapped the microvasculature network in the entorhinal cortex to understand its relationship to the progression of Alzheimer’s disease. Our research will help to identify key mechanisms and heterogeneity of Alzheimer’s disease pathogenesis, vulnerability, and potential resilience.