Publications

1. Hary, A., Chadha, S., Mercaldo, N., Smith, E., van der Kouwe, A., Fischl, B., Mount, C., Kozanno, L., Frosch, M., & Augustinack, J. (Accepted February 13, 2025). Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages.Acta Neuropathologica Communications. doi: 10.1186/s40478-025-01957-6. In press.
2. Oltmer, J., Williams, E. M., Groha, S., Rosenblum, E. W., Roy, J., Llamas-Rodriguez, J., Perosa, V., Champion, S. N., Frosch, M. P., & Augustinack, J. C. (2024). Neuron collinearity differentiates human hippocampal subregions: a validated deep learning approach. Brain communications, 6(5), fcae296. https://doi.org/10.1093/braincomms/fcae296
3. Llamas Rodríguez, J., van der Kouwe, A. J. W., Oltmer, J., Rosenblum, E., Mercaldo, N., Fischl, B., Marshall, M., Frosch, M. P., & Augustinack, J. C. (2024). Entorhinal vessel density correlates with phosphorylated tau and TDP-43 pathology. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 20(7), 4649–4662. https://doi.org/10.1002/alz.13896
4. Rosenblum EW, Williams EM, Champion SN, Frosch MP, Augustinack JC. The prosubiculum in the human hippocampus: A rostrocaudal, feature-driven, and systematic approach. J Comp Neurol. 2024 Mar;532(3):e25604. doi: 10.1002/cne.25604. PMID: 38477395.
5. Oltmer, J., Greve, D. N., Cerri, S., Slepneva, N., Llamas-Rodríguez, J., Iglesias, J. E., Van Leemput, K., Champion, S. N., Frosch, M. P., & Augustinack, J. C. (2023). Assessing individual variability of the entorhinal subfields in health and disease. The Journal of comparative neurology, 531(18), 2062–2079. https://doi.org/10.1002/cne.25538
6. Oltmer J, Rosenblum EW, Williams EM, Roy J, Llamas-Rodriguez J, Perosa V, Champion SN, Frosch MP, Augustinack JC. Stereology neuron counts correlate with deep learning estimates in the human hippocampal subregions. Scientific Reports. 2023 Apr 11;13(1):5884. doi: 10.1038/s41598-023-32903-y. PMID: 37041300
7. Llamas-Rodríguez J, Oltmer J, Marshall M, Champion S, Frosch MP, Augustinack JC. TDP-43 and tau concurrence in the entorhinal subfields in primary age-related tauopathy and preclinical Alzheimer’s disease. Brain Pathology. 2023 Jul;33(4):e13159. doi: 10.1111/bpa.13159. Epub 2023 Apr 10. PMID: 37037195
8. Williams EM, Rosenblum EW, Pihlstrom N, Llamas-Rodríguez J, Champion S, Frosch MP, Augustinack JC. Pentad: A reproducible cytoarchitectonic protocol and its application to parcellation of the human hippocampus. Frontiers in Neuroanatomy. 2023 Feb 9;17:1114757. doi: 10.3389/fnana.2023.1114757. PMID: 36843959
9. Oltmer J, Slepneva N, Llamas Rodriguez J, Greve DN, Williams EM, Wang R, Champion SN, Lang-Orsini M, Nestor K, Fernandez-Ros N, Fischl B, Frosch MP, Magnain C, van der Kouwe AJW, Augustinack JC. Quantitative and histologically validated measures of the entorhinal subfields in ex vivo MRI, Brain Communications. 2022 Mar 25;4(3):fcac074. doi: 10.1093/braincomms/fcac074. PMID: 35620167
10. Llamas-Rodríguez J, Oltmer J, Greve DN, Williams E, Slepneva N, Wang R, Champion S, Lang-Orsini M, Fischl B, Frosch MP, van der Kouwe AJW, Augustinack JC. Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer’s Disease. Journal of Alzheimers Disease. 2022;87(3):1379-1399. doi: 10.3233/JAD-215567. PMID: 35491780
11. Greve DN, Billot B, Cordero D, Hoopes A, Hoffmann M, Dalca AV, Fischl B, Iglesias JE, Augustinack JC. A deep learning toolbox for automatic segmentation of subcortical limbic structures from MRI images, Neuroimage. 2021 Dec 1;244:118610. doi: 10.1016/j.neuroimage.2021.118610. Epub 2021 Sep 25. PMID: 34571161
12. Saygin ZM, Kliemann D, Iglesias JE, van der Kouwe AJW, Boyd E, Reuter M, Stevens A, Van Leemput K, McKee A, Frosch MP, Fischl B, Augustinack JC; Alzheimer’s Disease Neuroimaging Initiative. High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas. Neuroimage. 2017 Jul 15;155:370-382. doi: 10.1016/j.neuroimage.2017.04.046. Epub 2017 May 4. PMID: 28479476
13. Augustinack, J. C., & van der Kouwe, A. J. (2016). Postmortem imaging and neuropathologic correlations. Handbook of clinical neurology, 136, 1321–1339. https://doi.org/10.1016/B978-0-444-53486-6.00069-7
14. Augustinack JC, van der Kouwe AJ, Salat DH, Benner T, Stevens AA, Annese J, Fischl B, Frosch MP, Corkin S. H.M.’s contributions to neuroscience: a review and autopsy studies. Hippocampus. 2014 Nov;24(11):1267-86. doi: 10.1002/hipo.22354. Epub 2014 Sep 23. PMID:    25154857
15. Augustinack JC, van der Kouwe AJ, Fischl B. Medial temporal cortices in ex vivo MRI. J Comp Neurol. 2013 Jul 24. doi: 10.1002/cne.23432. [Epub ahead of print] PMID: 23881818
16. Augustinack JC, Magnain C, Reuter M, van der Kouwe AJ, Boas D, Fischl B. MRI parcellation of ex vivo medial temporal lobe. Neuroimage. 2013 May 21. doi:pii: S1053-8119(13)00547-8. 10.1016/j.neuroimage.2013.05.053. [Epub ahead of print] PMID: 23702414
17. Augustinack JC, Huber KE, Stevens AA, Roy M, Frosch MP, van der Kouwe AJ, Wald LL, Van Leemput K, McKee AC, Fischl B; Alzheimer’s Disease Neuroimaging Initiative. Predicting the location of human perirhinal cortex, Brodmann’s area 35, from MRI. Neuroimage. 2013 Jan 1;64:32-42. doi: 10.1016/j.neuroimage.2012.08.071. Epub 2012 Aug 30. PMID: 22960087
18. Augustinack JC, Huber KE, Postelnicu, GM, Frosch MP, Pienaar, R, Fischl B (2012) Entorhinal verrucae correlate with surface geometry, 2012, Translational Neuroscience, 3 (2), 123-131.
19. Augustinack JC, Huber KE, Postelnicu, GM, Kakunoori S, van der Kouwe AJW, Frosch MP, Stein TS, Wald LL, Fischl B (2012) Entorhinal verrucae geometry is coincident and correlates with Alzheimer’s lesions: a combined neuropathology and high-resolution ex vivo MRI analysis Acta Neuropathologica 2012, Volume 123, Issue 1, Page 85-96.  PMID: 22160360
20. Augustinack JC, Helmer K, Huber KE, Kakunoori S, Zöllei L and Fischl B. Direct visualization of the perforant pathway in the human brain with ex vivo diffusion tensor imaging. Front. Hum. Neurosci. 2010 May 28;4:42. PMID: 20577631
21. Fischl B, Stevens AA, Rajendran N, Yeo BT, Greve DN, Van Leemput K, Polimeni JR, Kakunoori S, Buckner RL, Pacheco J, Salat DH, Melcher J, Frosch MP, Hyman BT, Grant PE, Rosen BR, van der Kouwe AJ, Wiggins GC, Wald LL, Augustinack JC.  Predicting the location of entorhinal cortex from MRI. Neuroimage. 2009 Aug 1;47(1):8-17. PMID: 19376238
22. Augustinack JC, van der Kouwe AJW, Blackwell ML, Salat DH, Wiggins CJ, Wiggins GC, Potthast A, Wald LL, Fischl BR.  Detection of Entorhinal Layer II Using 7T Magnetic Resonance Imaging.  Annals of Neurology, 2005 Apr; 57(4):489-94.
23. Augustinack, JC, Schneider, A, Mandelkow E-M, Hyman, BT.  Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer’s disease. Acta Neuropathol (Berl). 2002; 103:26-35.
24. Augustinack, JC, Sanders, J, Tsai, L-H, Hyman, BT.  Colocalization and fluorescence resonance  energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles.  J Neuropathol Exp Neurol. 2002;61:557-64.